Stroma is a poorly defined non-parenchymal component of virtually every organ with key roles in organ development, homeostasis, and repair. Studies of the bone marrow stroma have defined individual populations in the stem cell niche regulating hematopoietic regeneration and capable of initiating leukemia. Here, we use single-cell RNA sequencing (scRNA-seq) to define a cellular taxonomy […]

David T. Scadden, MD has been selected as the 2019 recipient of the Donald Metcalf Award from the ISEH. He is the Gerald and Darlene Jordan Professor of Medicine at Harvard Medical, and a Professor of Stem Cell and Regenerative Biology at Harvard University, Co-Founder and Co-Director of the Harvard Stem Cell Institute. David is a […]

CAMBRIDGE, Mass., Feb. 06, 2019 (GLOBE NEWSWIRE) — Editas Medicine, Inc. (NASDAQ: EDIT), a leading genome editing company, today announced that it has appointed David T. Scadden, M.D., to its Board of Directors, effective immediately. Dr. Scadden is a hematologist/oncologist and an expert on the medical applications of stem cell biology with a particular emphasis on its […]

We all have been touched by cancer.  And while our family and friends still die from its many forms, seemingly resistant to a cure, at the same time we read many stories about the potential for a cure, using personalized gene therapy, as opposed to the crude tools of chemotherapy and radiation.  So, what are […]

“For all the insight he offers into the hard science and thorny logistics of studying cancer, Dr. Scadden’s most moving passages consider the effect of the disease on the people who suffer from it and those who care for them.” ―The Wall Street Journal Reviews & Acknowledgements: Wall Street Journal Nature International Journal of Science […]

“If only,” wrote an ancient Japanese poet, “when one heard that Old Age was coming one could bolt the door….” Science is working on it. Aging is as much about the physical processes of repair and regeneration — and their slow-motion failure — as it is the passage of time. And scientists studying stem cell […]

Harvard University has completed a license agreement with Magenta Therapeutics, a startup company recently launched in Cambridge, for a portfolio of technologies with the potential to transform blood stem cell transplants from a “treatment of last resort” into a safer, more efficient therapy for patients with blood diseases and immune disorders. To date, even at […]

Harvard Stem Cell Institute (HSCI) researchers have used a colorful cell-labeling technique to track the development of the blood system and trace the lineage of adult blood cells traveling through the vast networks of veins, arteries, and capillaries back to their parent stem cells in the marrow. Developed at Harvard’s Center for Brain Science, the […]

A multi-institutional academic and industry research team led by investigators from Massachusetts General Hospital (MGH) and the Harvard Stem Cell Institute has identified a promising new approach to the treatment of acute myeloid leukemia (AML). In their report published online in Cell, the investigators identify a crucial dysfunction in blood cell development that underlies AML and […]

(WASHINGTON, August 4, 2016) The American Society of Hematology (ASH) will honor David Scadden, MD, of Massachusetts General Hospital and Harvard Medical School with the 2016 E. Donnall Thomas Lecture and Prize for his work on the bone marrow hematopoietic microenvironment. This lectureship and prize is named after the late Nobel Prize laureate and past president […]