tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche Biologic and medical implications of the bone marrow niche.
Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth Molecular regulators of HSC quiescence and unique metabolic dependencies of myeloid malignancies.
Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment Non-Traditional Roles of Blood and Bone Marrow.
Chromatin-state barriers enforce an irreversible mammalian cell fate decision Hematopoietic Stem cells have clone-specific epigenetically scripted behaviors and limited plasticity.
In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies HSC localization cues can be defined and manipulated to alter hematopoietic outcomes.
Image-seq: spatially resolved single-cell sequencing guided by in situ and in vivo imaging. Defining a stem cell niche.
A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia Defining a stem cell niche.
Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell. HSC localization cues can be defined and manipulated to alter hematopoietic outcomes., Publication
Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells. Non-Traditional Roles of Blood and Bone Marrow., Publication
Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease. Non-Traditional Roles of Blood and Bone Marrow., Publication
