Kameron A. Kooshesh, M.D.Resident Physician

Kameron is currently a resident physician-scientist at the Massachusetts General Hospital. Kameron graduated from Harvard College in 2016 with a degree in Stem Cell and Regenerative Biology and was awarded Departmental Honors and the Harvard Stem Cell Institute Internship Program for his work in building a genome-scale CRISPR/Cas9 system capable of dissecting enhancer regulation in early endodermal differentiation (Nature Biotechnology, 2016).

While working in the lab of Dr. Richard Maas at Brigham and Women’s Hospital, Kameron identified pathogenic mutations in families with complex genetic diseases and constructed pathophysiologic cellular models of patients as part of Brigham Genomic Medicine (NPJ Genomic Medicine, 2021; J Crohn’s Colitis, 2021). In one such project, Kameron identified a role for Piezo mechanotransduction in the cell cycle (PNAS, 2023).

Kameron completed his medical training in the Harvard-MIT Health Sciences and Technology (HST) Program at Harvard Medical School, from which he graduated magna cum laude. Kameron was given the American Society of Hematology HONORS Award for his work dissecting the role of the adult thymus in human health. Since joining the Scadden lab in January 2019, Kameron led a Mass General Brigham-wide retrospective cohort study that yielded epidemiologic, clinical outcomes, and basic immunological data that established the importance of the thymus in the adult immune system. Kameron’s work was the first demonstration that the removal of the adult thymus increases the risk of malignancy, autoimmune disease, and mortality (New England Journal of Medicine, 2023). Kameron’s current work focuses on the role of the adult thymus in a variety of disease states, including cancer, autoimmunity, and infection.

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